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OC Peptides

Epithalon

Epithalon

$175.00 USD
$175.00 USD
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Epithalon, also known as Epitalon, is a synthetic peptide that has captured the scientific community's attention for its researched potential in cellular rejuvenation, longevity, and vitality enhancement. Often referred to as the "Fountain of Youth," Epithalon is primarily recognized for its potential ability to influence telomere length, the protective caps at the ends of chromosomes, which are closely associated with aging.

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Epithalon
Epithalon
$175.00/ea		 $0.00
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Epithalon

Introduction to Epithalon

Epithalon, also known as Epitalon, is a synthetic peptide that has captured the scientific community's attention for its potential in cellular rejuvenation, longevity, and vitality enhancement. Often referred to as the "Fountain of Youth," Epithalon is primarily recognized for its ability to influence telomere length, the protective caps at the ends of chromosomes, which are closely associated with aging.


Research on Epithalon

Epithalon and Longevity

  • Histone Interaction: Studies have indicated that Epithalon may bind with histones, such as HI/6 and HI/3, interacting with DNA and potentially leading to increased neurogenic differentiation and protein synthesis in stem cells. This could enhance cellular functionality in various tissues.

Epithalon and Anti-Aging

  • Cell Proliferation and Regeneration: Research suggests that Epithalon may inhibit the synthesis of matrix metalloproteinase-9 (MM-9), which typically increases with age while promoting cellular proliferation and regeneration processes that usually decrease with age.

Epithalon in Fetal Cell Studies

  • Telomere Elongation: A study involving fetal fibroblastic cells showed that Epithalon could stimulate telomere development, potentially overcoming the Hayflick limit and extending the normal cell cycle.

Epithalon and Lymphocytic Cells

  • Chromosomal Impact: In geriatric subjects, Epithalon was found to activate ribosomal genes and decondensed heterochromatin, potentially restoring suppressed cellular activities due to aging.

Epithalon and Anti-Mutagenic Action

  • Chromosomal Aberrations: A study demonstrated that Epithalon might reduce chromosomal aberrations, particularly in models of accelerated aging, suggesting anti-mutagenic properties.

Epithalon and Anti-Cancer Properties

  • Tumor Growth Inhibition: Research on mice with reproductive organ tumors indicated that Epithalon could inhibit metastasis and tumor cell cycle progression, highlighting its anti-metastatic potential.

Epithalon in Hypophysectomized Birds

  • Thymus Gland Morphology: In birds with surgically removed pituitary glands, Epithalon was observed to restore the morphology of the thymus gland, regardless of age.

Epithalon and Melatonin Levels

  • Sleep and Hormone Regulation: Studies on aging monkeys and humans suggested that Epithalon could normalize melatonin levels, improving sleep patterns in elderly subjects.

Epithalon and Retinal Cells

  • Retinal Functionality: Clinical studies indicated that Epithalon might enhance bioelectric and functional activities in the retina, potentially reversing age-related degeneration.

Epithalon and Geroprotective Properties

  • Overall Health Improvement: A long-term study involving elderly subjects showed that Epithalon, alone or in combination with Thymalin, could improve functions in various 

bodily systems and decrease the incidence of common geriatric disorders.


Conclusion

Epithalon emerges from research as a peptide with significant potential in addressing various aspects of aging and cellular health. While the studies conducted so far provide promising insights into its capabilities, further research is necessary to understand its mechanisms, efficacy, and safety fully. 



References:

  1. Khavinson VKh. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144. PMID: 12374906. https://pubmed.ncbi.nlm.nih.gov/12374906/
  2. Khavinson, Vladimir et al. “AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.” Molecules (Basel, Switzerland) vol. 25,3 609. 30 Jan. 2020, doi:10.3390/molecules25030609. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037223/
  3. Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2. doi: 10.1023/a:1025493705728. https://pubmed.ncbi.nlm.nih.gov/12937682/
  4. Khavinson VKh, Kuznik BI, Tarnovskaia SI, Lin’kova NS. [Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data]. Adv Gerontol. 2014;27(3):399-406. Russian. https://pubmed.ncbi.nlm.nih.gov/25826983/
  5. Lin’kova, N.S., Drobintseva, A.O., Orlova, O.A. et al. Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro . Bull Exp Biol Med 161, 175–178 (2016).
  6. Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cell. Bull Exp Biol Med. 2004 May;137(5):503-6. doi: 10.1023/b:bebm.0000038164.49947.8c. PMID: 15455129. https://pubmed.ncbi.nlm.nih.gov/15455129/
  7. Khavinson VKh, Lezhava TA, Monaselidze JR, Jokhadze TA, Dvalishvili NA, Bablishvili NK, Trofimova SV. Peptide Epitalon activates chromatin at the old age. Neuro Endocrinol Lett. 2003 Oct;24(5):329-33. PMID: 14647006. https://pubmed.ncbi.nlm.nih.gov/14647006/
  8. Rosenfeld SV, Togo EF, Mikheev VS, Popovich IG, Khavinson VKh, Anisimov VN. Effect of Epithalon on the incidence of chromosome aberrations in senescence-accelerated mice. Bull Exp Biol Med. 2002 Mar;133(3):274-6. doi: 10.1023/a:1015899003974. PMID: 12360351. https://pubmed.ncbi.nlm.nih.gov/12360351/
  9. Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I. Effect of the synthetic pineal peptide Epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo. 2006 Mar-Apr;20(2):253-7. PMID: 16634527. https://pubmed.ncbi.nlm.nih.gov/16634527/
  10. Pateyk AV, Baranchugova LM, Rusaeva NS, Obydenko VI, Kuznik BI. Effect of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the morphology of the thymus in hypophysectomized young and old birds. Bull Exp Biol Med. 2013 Mar;154(5):681-5. doi: 10.1007/s10517-013-2029-0. PMID: 23658898. https://pubmed.ncbi.nlm.nih.gov/23658898/
  11. Korkushko OV, Lapin BA, Goncharova ND, Khavinson VKh, Shatilo VB, Vengerin AA, Antoniuk-Shcheglova IA, Magdich LV. [Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people]. Adv Gerontol. 2007;20(1):74-85. Russian
  12. Khavinson V, Razumovsky M, Trofimova S, Grigorian R, Razumovskaya A. Pineal-regulating tetrapeptide Epitalon improves eye retina condition in retinitis pigmentosa. Neuro Endocrinol Lett. 2002 Aug;23(4):365-8. PMID: 12195242. https://pubmed.ncbi.nlm.nih.gov/12195242/
  13. Khavinson VKh, Morozov VG. Geroprotektornaia éffektivnost’ timalina i épitalamina [Geroprotective effect of thymalin and Epithalamin]. Adv Gerontol. 2002;10:74-84. Russian. PMID: 12577695. https://pubmed.ncbi.nlm.nih.gov/12577695/
  14. Korkushko OV, Khavinson VKh, Shatilo VB, Antonyuk-Shcheglova IA. Geroprotective effect of Epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging. Bull Exp Biol Med. 2006 Sep;142(3):356-9. English, Russian. doi: 10.1007/s10517-006-0365-z. PMID: 17426848. https://pubmed.ncbi.nlm.nih.gov/17426848/