OC Peptides
Ipamorelin
Ipamorelin
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Ipamorelin, a synthetic peptide composed of five amino acids, is at the forefront of research for its ability to stimulate natural growth hormone production. Ipamorelin is known for its researched specificity and targeted action, offers a promising avenue for studies in muscle growth, bone health, and overall well-being.
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Peptide Product Usage
PEPTIDE PRODUCTS ARE INTENDED AS A RESEARCH CHEMICAL ONLY.
This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.
Ipamorelin
Introduction to Ipamorelin
Ipamorelin, a synthetic peptide composed of five amino acids, is at the forefront of research for its ability to stimulate natural growth hormone production. This peptide, known for its specificity and targeted action, offers a promising avenue for studies in muscle growth, bone health, and overall well-being.
Understanding Ipamorelin
- Chemical Structure: Ipamorelin's structure is denoted as H-Aib-His-D-2Nal-D-Phe-Lys-NH2, with a molecular formula of C38H49N9O5.
- Mechanism of Action: As a ghrelin mimetic, Ipamorelin binds to ghrelin receptors in the pituitary gland, stimulating the release of growth hormone stimulating hormone, which in turn signals the release of growth hormone.
Distinct Advantages
- Targeted Action: Unlike other ghrelin mimetics, Ipamorelin is highly specific in its action, primarily influencing growth hormone release without significantly triggering the body's stress response.
Research Highlights on Ipamorelin
Bone Growth Stimulation
- Counteracting Skeletal Muscle Catabolism: Studies have shown that Ipamorelin can counteract the adverse effects of glucocorticoids on bone, suggesting potential applications in bone health and recovery.
- Increased Bone Mineral Content: Research in female rats indicated that Ipamorelin administration resulted in denser, stronger bones.
- Long Bone Growth: Early studies, including one from 1999, observed that Ipamorelin could increase the length of long bones, like the tibia in rats.
Muscle Growth Potential
- Digestive System Impact: While Ipamorelin is known to stimulate smooth muscle in the digestive lining, its direct effects on skeletal muscle growth have not yet been definitively proven in scientific research.
- Glucocorticoid Neutralization: Studies suggest that muscle strength in rats was higher when Ipamorelin was administered alongside glucocorticoids compared to glucocorticoids alone.
Vascular Health
- Angiogenesis: As a ghrelin mimetic, Ipamorelin may share ghrelin's ability to stimulate angiogenesis the growth of new blood vessels, which is significant for heart health and physical performance.
Collagen Synthesis
- Cartilage and Skin Repair: Research indicates that ghrelin can promote the growth and repair of cartilage and skin, potentially through its effects on collagen. As Ipamorelin mimics ghrelin, it may also exhibit these effects, though specific studies on Ipamorelin are needed.
Conclusion
Ipamorelin represents a significant area of interest in peptide research, particularly its targeted action on growth hormone release and potential applications in bone health, muscle growth, and tissue repair. While the research is promising, further studies are necessary to fully understand its mechanisms and possible therapeutic uses.
References
- N Mohammadi E, Louwies T, Pietra C, Northrup SR, Greenwood-Van Meerveld B. Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics. J Exp Pharmacol. 2020;12:267-274. Published 2020 Aug 5. doi:10.2147/JEP.S249747
- National Center for Biotechnology Information. PubChem Compound Summary for CID 9831659, Ipamorelin. https://pubchem.ncbi.nlm.nih.gov/compound/Ipamorelin. Accessed Oct. 12, 2021.
- Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-561. doi:10.1530/eje.0.1390552
- Andersen NB, Malmlöf K, Johansen PB, Andreassen TT, Ørtoft G, Oxlund H. The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats. Growth Horm IGF Res. 2001;11(5):266-272. doi:10.1054/ghir.2001.0239
- Svensson J, Lall S, Dickson SL, et al. The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats. J Endocrinol. 2000;165(3):569-577. doi:10.1677/joe.0.1650569
- Johansen PB, Nowak J, Skjaerbaek C, et al. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Horm IGF Res. 1999;9(2):106-113. doi:10.1054/ghir.1999.9998
- Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C. Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus. J Exp Pharmacol. 2012;4:149-155. Published 2012 Oct 19. doi:10.2147/JEP.S35396
- Wang J, He L, Huwatibieke B, et al. Ghrelin Stimulates Endothelial Cells Angiogenesis through Extracellular Regulated Protein Kinases (ERK) Signaling Pathway. Int J Mol Sci. 2018;19(9):2530. Published 2018 Aug 26. doi:10.3390/ijms19092530
- Liang ZT, Li J, Rong R, et al. Ghrelin up-regulates cartilage-specific genes via the ERK/STAT3 pathway in chondrocytes of patients with adolescent idiopathic scoliosis. Biochem Biophys Res Commun. 2019;518(2):259-265. doi:10.1016/j.bbrc.2019.08.044
- Fan L, Chen J, Tao Y, et al. Enhancement of the chondrogenic differentiation of mesenchymal stem cells and cartilage repair by ghrelin. J Orthop Res. 2019;37(6):1387-1397. doi:10.1002/jor.24224
- Mericq V, Cassorla F, Salazar T, et al. Effects of eight months treatment with graded doses of a growth hormone (GH)-releasing peptide in GH-deficient children. J Clin Endocrinol Metab. 1998;83(7):2355-2360. doi:10.1210/jcem.83.7.4969
- Bowers CY, Reynolds GA, Durham D, Barrera CM, Pezzoli SS, Thorner MO. Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. J Clin Endocrinol Metab. 1990;70(4):975-982. doi:10.1210/jcem-70-4-975
- Laferrère B, Abraham C, Russell CD, Bowers CY. Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men. J Clin Endocrinol Metab. 2005;90(2):611-614. doi:10.1210/jc.2004-1719
- Berlanga-Acosta J, Abreu-Cruz A, Herrera DGB, et al. Synthetic Growth Hormone-Releasing Peptides (GHRPs): A Historical Appraisal of the Evidences Supporting Their Cytoprotective Effects. Clin Med Insights Cardiol. 2017;11:1179546817694558. Published 2017 Mar 2. doi:10.1177/1179546817694558
- World Anti-Doping Agency. World Anti-Doping Code International Standard Prohibited List 2022. WADA