OC Peptides
TB500
TB500
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TB-500, also known as Thymosin Beta 4 or TB-4, is a synthetic peptide closely resembling the naturally occurring protein Thymosin Beta 4. TB-500 has become a subject of interest in various research fields due to its potential to promote angiogenesis, accelerate wound healing, and influence processes like tumor cell metastasis and hair growth.
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PEPTIDE PRODUCTS ARE INTENDED AS A RESEARCH CHEMICAL ONLY.
This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.
TB500
Introduction to TB-500
TB-500, also known as Thymosin Beta 4 or TB-4, is a synthetic peptide closely resembling the naturally occurring protein Thymosin Beta 4. This peptide has become a subject of interest in various research fields due to its potential to promote angiogenesis, accelerate wound healing, and influence processes like tumor cell metastasis and hair growth.
Understanding TB-500
- Structure and Properties: TB-500 is a 43 amino acid peptide known for its high solubility in water and lightweight structure. It is notably abundant in wound fluid, especially in the presence of blood platelets.
- Potential Anti-Inflammatory Effects: Research suggests that TB-500 may offer anti-inflammatory benefits and could be instrumental in neurological healing and recovery in critical areas such as the spinal cord, heart, and skin.
Research Highlights on TB-500
Initial Research and Discovery
- Thymus Gland Functionality: The initial research by Dr. Goldstein and Professor Abraham White in 1964 focused on proteins secreted by the thymus gland, leading to the discovery of Thymosin and its potential impact on immune deficiency and hormone release.
TB-500 and Wound Healing
- Acute Wounds: A 1999 study on rats demonstrated that TB-500 could significantly enhance re-epithelialization and wound contraction, suggesting its role in promoting angiogenesis and collagen deposition.
- Chronic Wounds: Further studies involving various animal models with different health conditions showed that TB-500 accelerated wound healing, including in phase 2 clinical trials for human subjects with stasis and pressure ulcers.
TB-500 and Cardiac Function
- Pulmonary Hypertension: Research indicates that TB-500 may specifically act on the Notch3-Col 3A-CTGF gene axis in mice, potentially reducing right ventricular hypertrophy and aiding in the management of pulmonary hypertension.
TB-500 and Hair Growth
- Hair Follicle Stimulation: A 2003 study on mice revealed that TB-500 could increase the number of hair shafts and follicles, inducing hair growth. This was further supported by observed changes in mRNA and protein levels in TB-500-treated mice.
Conclusion
TB-500 presents itself as a peptide with significant potential in various areas of medical research. Its capabilities in enhancing wound healing, potentially aiding in cardiac function, and stimulating hair growth make it a notable subject in regenerative medicine and beyond. While the current research provides promising insights, further studies are essential to understand its mechanisms and potential therapeutic applications fully.
References:
- Kleinman HK, Sosne G. Thymosin β4 Promotes Dermal Healing. Vitam Horm. 2016;102:251-75. doi: 10.1016/bs.vh.2016.04.005. Epub 2016 May 24.
- Julia Parmley, A Life-Saving Discovery, January 04, 2010.
- Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008 May 15;453(7193):314-21. doi: 10.1038/nature07039. PMID: 18480812.
- Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012 Nov 23;1265:57-69. doi: 10.1016/j.chroma.2012.09.043. Epub 2012 Sep 23.
- Katherine M. Malinda et.al, Thymosin β4 Accelerates Wound Healing, Journal of Investigative Dermatology, Volume 113, Issue 3, 1999, Pages 364-368, ISSN 0022-202X.
- Treadwell T, Kleinman HK, Crockford D, Hardy MA, Guarnera GT, Goldstein AL. The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients. Ann N Y Acad Sci. 2012 Oct.
- Wei C, Kim IK, Li L, Wu L, Gupta S. Thymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy. PLoS One. 2014 Nov 20;9(11):e110598.
- Gao, Xy., Hou, F., Zhang, Zp. et al. Role of thymosin beta 4 in hair growth. Mol Genet Genomics 291, 1639–1646 (2016).
- Esposito S, et al. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential. Drug Test Analysis. 2012 Sep.
- Piao Z, Hong CS, Jung MR, Choi C, Park YK. Thymosin β4 induces invasion and migration of human colorectal cancer cells through the ILK/AKT/β-catenin signaling pathway. Biochem Biophys Res Commun. 2014 Sep 26;452(3):858-64.
- Study of Thymosin Beta 4 in Patients with Pressure Ulcers https://www.clinicaltrials.gov/ct2/show/NCT00382174
- A Phase 2 study of the effect of Thymosin Beta 4 on Wound Healing in Patients https://www.clinicaltrials.gov/ct2/show/NCT00311766